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Hereditary motor and sensory neuropathy type Lom, initially identi®ed in Roma (Gypsy) families from Bulgaria, has been mapped to 8q24. Further re®ned mapping of the region has been undertaken on DNA from patients diagnosed across Europe. The re®ned map consists of 25 microsatellite markers over approximately 3 cM. In this collaborative study we have identi®ed a number of historical recombinations resulting from the spread of the hereditary motor and sensory neuropathy type Lom gene through Europe with the migration and isolation of Gypsy groups. Recombination mapping and the minimal region of homozygosity reduced the original 3 cM hereditary motor and sensory neuropathy type Lom region to a critical interval of about 200 kb. q

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