Aim. To identify the difference in the detection of yeasts of the genus Candida and their species composition in people with gastrointestinal pathology and in healthy people undergoing a regular medical checkup.Materials and methods. Clinical trial material comprised biological material from patients undergoing regular medical checkup (control group) and patients with intestinal pathology. Following the detection of fungal colonies on Sabouraud medium, identification was carried out using chromogenic agar. A number of strains were identified via mass spectrometry.Results. The study results show that the frequency of occurrence of the genus Candida is more than three times higher in patients with intestinal pathology. In addition, the study groups revealed the differences in the species composition. Candida krusei is more than 5 times more common in cases of gastrointestinal pathology.Conclusion. Due to the differences in the frequency and species composition of yeasts of the genus Candida isolated from the intestine, specialists should diagnose intestinal diseases and choose antimycotic therapy in a meticulous way.

The article highlights the history of Morton's neuroma study. The epidemiology, etiology, and main risk factors that act as a trigger in the development of this pathology are presented. The main pathogenesis links are revealed. Modern ideas about the development of the pathological process and the results of morphological studies are reflected, indicating that a pseudoneuroma is formed on the intermetatarsal nerve during microtrauma. Modern methods of diagnostics and criteria for making a diagnosis are listed. The role of CT, MRI, radiography, and ultrasound is shown. The clinical picture of the disease is presented. The measures for the prevention and conservative treatment of Morton's neuroma are described. The significance of therapeutic and diagnostic blockades is indicated, as consequent regression of the pain syndrome is a confirmation of Morton's neuroma in the patient. The diseases with which it is necessary to differentiate the described pathology are listed. The main methods of surgical interventions performed for Morton's neuroma are presented.

No abstract

<p>In recent years, much attention is paid to oral microbial landscape, which is violated in various pathological conditions. In the treatment of candidiasis not always take into account the sensitivity to antimycotics and background violations of the microflora that can lead to relapse. A sensitivity analysis fungus of the genus Candida to antimycotics has been conducted and study on the prevalence of clinically significant representatives of microflora of an oral cavity in candidiasis. It is revealed, those on a background of increase of fungi of the genus Candida to the etiology of significant digits in the composition of the microbiocenosis of the mucous membranes of the mouth is also increasing representatives of pathogenic flora and decrease the prevalence of normal microorganisms. The study showed the prevalence of different sensitivity of fungi of the genus Candida to applied antimycotics.</p>

Urinary tract infections (UTIS) in the Russian Federation are widespread and often occur in children, adults, most often affecting people in the most active period of their lives. The course of UTI is determined by a number of predisposing factors, such as age, sex, General condition of the patient, the presence of immunocompromising factors. Uncontrolled use of antibacterial therapy is often a predisposing factor in the chronization of the process in the upper urinary tract.To determine the identity of E. coli strains. In 2019, biological material was collected from 50 patients of «Altai regional hospital for war veterans» with urinary tract infections (chronic pyelonephritis and chronic cystitis) to assess bacteriuria. According to the results of bacteriological research, 23 strains of E. coli were isolated. After that, molecular genetic analysis was performed using the Random Amplified Polymorphic DNA method of E. Coli strains obtained from patients with urinary tract infections, and their identity was evaluated. The results of this study showed that the method used is a reliable method of epidemiological mapping and determination of relationships between closely related varieties and strains of microorganisms isolated from various sources. Carrying out one bacteriological examination of urine in urinary tract infections is not enough, only high-tech techniques allow establishing the exact type of the causative agent of these infections and will allow selecting the correct appointment of antimicrobial drugs in patients with this group of infections.