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Thus, ESBL producing organisms pose a major problem for clinical therapeutics. Because of the close contact between dogs and man, and aimless utilization of antibiotics especially cephalosporins in veterinary sector, these animals have turned into potential source of ESBL producing bacteria, thereby prompting the transfer of multidrug resistant strains in human. So far no studies have been conducted regarding the prevalence of ESBL among animals in Kerala. Because of the alarming rise in the number of these resistant strains, there is a urgent need for regular area based monitoring of the antibiogram profile of the various bacterial organisms associated with clinical infections in animals which could fluctuate throughout the years and from site to site. This could provide adequate data prompting the authorities to formulate strict antibiotic usage guidelines in veterinary and human sector.