The title compounds were synthesized by condensation of 3-acetyl chromen-2-one with benzaldehyde in presence of alcoholic sodium hydroxide to get intermediate 3-(3-phenyl acryloyl) chromen-2-one, which were further treated with hydrazine hydrate to get 3-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl) chromen-2-one. The latter were refluxed with various amino compounds and various aldehyde derivatives on water bath for 5 h to afford title compounds. All the compounds were tested for their antibacterial and antifungal activities by the cup plate method.

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Some new 3-(substituted)-chromen-2-one have been synthesized by condensation of 3-acetylchromen-2-one with various aromatic aldehyde in presence of ethanol and alkali. The synthesized compounds were identified by spectral data and screened for their antibacterial activity againstB. pumilis, B. substilisandE. coliand antifungal activity againstA. nigerandCandida albicans. Among the synthesized compounds, some compounds of aryl chromen, which are having electron releasing substituent such as methoxy and hydroxyl at various positions, showed moderate to considerable antibacterial and antifungal activities.

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Hypercholesterolemia is the leading cause for the development of various diseases made pharmaceutical companies to turn towards the herbal products with fewer side effects. In the present research, the hypocholesterolemic activity of Enicostemma axillare (EA) along with their phytochemical evaluation has been done. Preliminary phytochemical analysis was carried out in different extracts of EA. The hypocholesterolemic effect of 85 % methanolic extract of EA was evaluated in fructose induced hyperlipidemic animals. Antioxidant enzymes such as catalase, TBARS, GSH, GST and lipid profile such as cholesterol, LDL, VLDL, HDL and Triglycerides were analyzed in heart and plasma samples. Administration of EA decreases the lipid profile and TBARS significantly (p<0.05). Likewise, EA administration increases the antioxidant and HDL significantly (p<0.05). The results reveal that EA is a rich source for phytoconstituents and can be used as a potent hypocholesterolemic and antioxidant agent in pharmaceutical industry.