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Particular attention when developing drugs is paid to the choice of the rational technology. The technological process is an important aspect affecting the quality and stability of a drug, and should consist of a system of interconnected and evidence-based operations. The effect of the active components of "Dentatryhin" gel (triclosan, aminocaproic acid and lavender oil) in the concentrations specified on the structural-mechanical and physicochemical properties of test samples of the gels based on Carbomer 934 P has been studied; it is important from the point of view of consumer and technological characteristics of the medicinal product. It has been proven that the combined gel "Dentatryhin" developed for treating gingivitis represents a structured system with moderate thixotropic properties and satisfactory consumer characteristics. The rational technology of a dental gel has been experimentally determined; it consists of several sequential steps such as preparing a gel base, first introducing the alcohol solutions of triclosan and lavender oil into it, and then an aqueous solution of aminocaproic acid with the subsequent homogenization.

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Влияние снижения тонуса сосудов различных регионов на показатели центральной гемодинамики пациентов с выраженной систолической дисфункцией левого желудочка 1 Федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр имени В. А. Алмазова» Министерства здравоохранения Российской Федерации 197341, Россия, Санкт-Петербург, ул. Аккуратова, д. 2 2 Федеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет им. А. И.