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A clinical case of a patient who underwent a thymusectomy for thymoma at the age of 50 is presented. Subsequently, the patient developed immune dysfunction with recurrent esophageal candidiasis and oropharyngeal candidiasis caused by Candida albicans. The patient also suffers from persistent widespread mycosis of the skin and nail plates caused by Trichophyton rubrum, autoimmune gastritis and benign neoplasms of the oral cavity and intestines. Repeated courses of treatment with fluconazole led to the emergence of Candida albicans resistance to azole antimycotics. Treatment with irrigation of Amphotericin solution B in the oropharynx and in the esophagus was effective.

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