Additive technologies have been actively developing in recent decades. Their introduction into medicine provides new opportunities for reconstructive treatment, including animal patients.One of the most popular materials for 3D printing is titanium and titanium alloys. Their demand is explained by the properties of mechanical biocompatibility, strength and elasticity comparable to bone.The purpose of this review was to summarize data on the use of 3D printed titanium implants for the treatment of animals with bone defects. The search for information was carried out in the databases of scientific data of domestic and foreign literature and medical resources.The conducted studies have shown that the use of 3D printing technology makes it possible to design and create individual implants and endoprostheses based on images of each patient, exactly corresponding to the area of the defect. This approach reduces the time of surgical intervention, reduces the time of postoperative recovery.Possibility of obtaining the necessary specified porosity and surface roughness, which leads to a decrease in the micromovement of the boneimplant structure and promotes good osseointegration. These properties are the advantages of 3D printing implants made of titanium and titanium alloys.The given practical examples of the use of individual three-dimensional titanium implants show the possibilities of using additive technology for veterinary medicine.

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The use of tissue-engineered products (TEP) from decellularized extracellular matrix (dECM) to treat deep skin lesions is a tissue engineering method that promotes regenerative healing. Cell-free preparations reproduce the hierarchical complexity of tissues, mimic structural, biochemical and mechanical signals that are necessary to attract cells, and are a source of bioactive molecules. The human umbilical cord biomaterial has a fetal phenotype with extra-embryonic origin, and therefore is available and has no ethical limitations in its use. The tissue engineering laboratory at Kirov Military Medical Academy developed and patented a TEP from the highly regenerative human umbilical cord in the form of matrix and hydrogel matrix. To study its regenerative potential, lyophilisates of tissue-engineered solid-state and hydrogel matrices were implanted around mini pig fullthickness wounds in vivo. The external signs of inflammatory response and the histological images of biopsy specimens from the lyophilizate implantation areas were analyzed. The effect of nutrient media, «conditioned» with lyophilizates of both matrices, on the viability and migration activity of fibroblast-like cells, isolated from mini pig skin, was investigated. The matrix lyophilisates showed good biocompatibility and bioactivity in in vitro and in vivo experiments. Implantation of the samples promoted faster formation of mature epidermis compared to the control.

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