Microbes are associated inside and outside tissue parts of producers like plants, lichen, algae and phototrophic bacteria. Biofertilizer bacteria, fungi, algae and protozoa provide the suitable environment condition, nutrition constituents and inhibit harmful microorganism from rhizosphere zone. Biofertilizer and biocontrol microbes play key roles for improved soil texture, secreting, hormones, antibiotics and various stress signal compounds, enhancement plant parts elongation and prevent pathogen microbial population. Plant growth promotion rhizosphere microorganisms can improve crop tolerance for the non- living stresses such as drought, heat and salinity and living stress such as soil borne pathogens, over load of the microbial population liable to turn out to be more incessant as various atmosphere design keep on creating. Plant disease major issue for loss of productivity and unsafe for living organism due to chemical pesticides, insecticides, fungicides, bactericides and chemical fertilizer. Due to its high potential as an alternative/complement to these pesticides, biological disease control is now generally recognized and constitutes a low cost-efficient eco-friendly biofertilizer, biocontrol, biopesticide and bioinsecticide.