Background and Objectives: This systematic review aimed in investigating the effectiveness of theobromine as a remineralizing agent on early enamel lesions. Materials and Methods: An electronic search was performed in the three databases (Google scholar, Pubmed and Medline) using keywords. Articles published in the English language and without any time limit were and 6038 articles were collected. Among the collected articles, considering the inclusion and exclusion criteria, a total of eight articles were selected for this systematic review. Results: All the selected articles assessed and compared the remineralization potential of theobromine containing agents (solution, dentifrices, gel) with fluoridated remineralizing agents. Majority of the selected studies indicated that theobromine is an effective remineralizing agent. Conclusion: The novel theobromine has remineralizing potential equivalent to fluoridated agents and it can be considered as an alternative for fluoridated remineralizing agents.