AIM: Aim of the study is to determine the effect of oral sodium bicarbonate in maintaining acid base balance and quality of life in chronic kidney disease and long-term acidosis patients. Study Design: A prospective observational study. Study Population: Approximately 174 people who came to nephrology department, Selected based upon inclusion and exclusion criteria. Study Criteria / Patient Enrollment: Patients are enrolled in study based on inclusion and exclusion criteria. Inclusion Criteria: The patients who are diagnosed with CKD and receiving oral sodium bicarbonate as part of treatment Exclusion Criteria: the patients who are having other comorbidities, hypertension, diabetes, and other cardiovascular problems who are not given with oral sodium bicarbonate. Study Duration : 6 months (December 2021- May 2022). Methodology: A prospective observational study on effect of oral sodium bicarbonate in maintaining acid base balance and quality of life in chronic kidney disease and long term acidosis patient’s which was carried out in the Department of nephrology. Results: Most of the patients are in between the age of 70-80 years, married, with good nutritional status, with minimum 5 months of CKD, approximately 50%of the patients are suffering from HTN along with CKD followed by diabetes. Patients are using OSB for a minimum of 5 months with 500mg dose given thrice a day, along with Calcium channel blockers and pantoprazole. OSB is given as a oral tablet. Conclusion: Oral bicarbonate is widely used to correct acidosis in advanced CKD, this is not underpinned by trial evidence, and real uncertainty exists regarding the balance of benefit and risk for this intervention. That we concluded that most of the patients using OSB was analyzed from nephrology department in QOL, in maintaining acid-base balance was observed in CKD patients.