Mulberry leaf is a sole food of silkworm Bombyx mori on which it feeds and produces silk called mulberry or mori silk. Due to its quality, mori silk has huge demand in national and international market and earns a valuable foreign exchange for the country. Weeds are of great menace as they interfere with production and quality of mulberry leaf and also add significant amount to the cost of cultivation. The factors which are congenial for heavy weed growth in mulberry are continuous mono-cropping, wider spacing coupled with regular application of manures and fertilizers after each crop harvest for maintenance of plantation. The reduction in production and quality of leaf has direct correlation with production of cocoons and quality silk. If losses due to weeds can be reduced by half from present level of 30-40%, leaf yield of mulberry will increase by 9-12 MT ha-1 year-1 which can be utilized to produce 55-73.5 kg ha-1 year-1 more raw silk to enhance the silk production of country. The effective weed control involves identification of weed flora, method of weed control and judicious combination of effective weed control methods. Depending upon soil type, agro climatic and ecological conditions, the nature and intensity of weed flora, their competitiveness varies. A total of 57-141 weed species belongs to 28-44 families have been reported in mulberry field across the country. Manual weeding in mulberry is an age old practice in India, but it is a tedious, expensive and time consuming. Black polyethylene mulching alone has been found economically advantageous over manual weeding in mulberry plantation. However no single method viz., manual weeding, cover crop intercropping, herbicide and mulching found effective in weed control as compared to integrated method of weed control. Spraying of pre-emergence and early post emergence herbicides keeps the mulberry plantation in weed free conditions during the early stages. At later stage, when second flush of weeds attains peak after 30 days of pruning, spraying of herbicide is not possible due to chance of residual toxicity to the silkworm. Integration of pre herbicide followed by manual weeding at later stage or integration of hand weeding after pruning followed by either cover crop intercropping or mulching may helps to reduce damage due to weed, prevent silkworm from residual toxicity of herbicide and reduces manual weeding cost to some extent. Hence a brief review was presented to find out the influence of different weed management method in mulberry.