In modern conditions, improving the working conditions of the working population is a priority area of activity in the field of occupational safety and health. The purpose of the research was to study the gender characteristics of occupational pathology in the Republic of Bashkortostan in 2000-2019. Materials and methods. The analysis of the structure of occupational pathology and statistical processing using the Microsoft Excel application software package was carried out. Results. The performed study demonstrated the presence of pronounced features of working conditions and occupational pathology in men and women. Men are more likely than women to work in harmful working conditions with exposed to noise factor, general and local vibration, increased severity and intensity of the labor process, and their combined effect. Conclusion. Attention should be paid to the development of sanitary and hygienic measures aimed at eliminating the causes of occupational pathology or its risk.