The purpose of this article is to review the possibility of practical use of the concept of D-optimality in response surface design. Second order quasi-D-optimum designs on a cube have been built and their high efficiency proved. Using the computer, a number of different second order response surface designs, previously built, have been compared. It has been proved that the D-optimum concept, being more general than the rotatable one, can be used as the theoretical basis for building and comparing response surface designs in use.

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