Both bee products themselves and their combinations are widely represented in the domestic pharmaceutical market, however, modern experimental studies of the biological activity of these compounds are few, and in many of the existing publications the authors describe an extremely wide and controversial range of therapeutic effects.The aimof the study is to analyze the experimental works on the study of biological activity of bee products.Materials and methods.The study was conducted using search and information (eLibrary, PubMed, CyberLeninka, ResearchGate) and library databases (Russian State Library, Central Scientific Agricultural Library). In the designated databases, publications were searched by such terms as “biological activity”, “royal jelly”, etc. The depth of the search was not limited.Results and discussion.The analysis of the published works shows that such substances as bee venom and royal jelly have experimentally confirmed their biological activity. In both cases, the active substances have been described and a review of their detected biological activity has been carried out.Conclusion. The authors suggest that when developing the method of laboratory synthesis of decene acids, it can be possible to carry out their large-scale preclinical research, which may become the basis for the creation of a drug with a selective effect.

Salmonella is one of the leading bacterial pathogens of acute diarrhea as well as foodborne outbreaks. Salmonellosis can occur as gastroenteritis with the development of complications and generalization of infection, also the extra intestinal diseases that require antibiotic therapy are often registered. Currently, the effectiveness of many antibiotics is reduced due to the development of resistance in Salmonella. National Salmonella surveillance systems monitor Salmonella resistance to «critically important for medicine» antibiotics (extended-spectrum cephalosporins and fluoroquinolones), as well as multidrug resistance. Quinolone-resistant Salmonella is considered as a high-priority resistant pathogen by the World Health Organization. The article describes the current situation on salmonellosis in the world. Foreign and Russian current data about the leading Salmonella serotypes in different regions of the world are presented. The prevalence of clinically significant resistance depending of the Salmonella serotypes in countries with state monitoring systems is shown. The authors described the leading molecular resistance mechanisms (chromosomal and plasmid mediated) and showed their prevalence in different Salmonella serotypes. The article gives the information about Salmonella successful international multidrug resistant clones with specific resistance phenotypes and genotypes. The authors describe the molecular methods for detection of resistance mechanisms, and show the necessity and significance of antimicrobial susceptibility monitoring in the epidemiological Salmonella surveillance.

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