Food and nutrients are essential for the body's regular functioning. They aid in the preservation of an individual's health and the reduction of the danger of certain diseases. As a result of the widespread recognition of this fact, a link was established between “nutrition and health,” and the term “nutraceuticals” was coined. Nutraceuticals are therapeutic foods that aid in maintaining well-being, enhancing health, regulating immunity, and preventing as well as curing certain diseases. Nutraceuticals might thus be thought of as one of the missing pieces in a person's overall health. More than any other illness, cardiovascular disease has numerous risk variables that are susceptible to nutraceutical treatment. It is critical to see nutraceuticals' ability to improve cardiovascular risk factors as a huge opportunity in the treatment of a disease that affects so many people. Nutraceuticals show promise in clinical treatment since they have the potential to minimize the risk of chemotherapyrelated side effects while also lowering the overall cost of health care. In this study, an attempt was made to summarize some of the most recent research findings on garlic, omega-3 fatty acids, soy products, dietary fibers, vitamins, antioxidants, plant sterols, flavonoids, prebiotics, and probiotics that have beneficial effects on the heart, as well as to provide insight into a bioinformatics approach to identify novel therapeutic biomarkers in order to keep practitioners up to date.

In this study, we made an attempt to attenuate the dexamethasone induced hypertension through Biochanin-A (BCA) in experimental rats. Hypertension was induced in male albino Wistar rats by subcutaneous administration of dexamethasone (10μg/kg body weight). The rats were orally treated with BCA (10mg/kg body weight) once daily for 45 days and Nicorandil-treated group (6mg/kg body weight) included for comparison. We evaluated the changes in mean arterial pressure, heart rate, blood pressure, vascular function, oxidative stress markers, and gene expression of histone deacetylases (HDAC)-1, HDAC-2, and HDAC-8. Administration of BCA or Nicorandil showed noteworthy improvement in vascular function in experimental rats. Moreover, aortic eNOS expression was down regulated, and NADPH oxidase subunit p47phox was up regulated in hypertensive rats. The antihypertensive effects of BCA were connected with concomitant downregulation of p47phox expression and upregulation of eNOS expression. Dexamethasone exposure led to increased mRNA expression of HDACs expression in the kidneys and these were restored after BCA administration. In conclusion, our results are, therefore, BCA reduces hypertension in experimental rats and suggests that BCA might be used against the hypertension.

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Background: The ideal medications for diabetes mellitus (DM) should have less or no adverse effects, thus screening on the antidiabetic activities of plant-based products is in urgent need. Paneer is the fundamental nutritious and complete native dairy products, and natural products incorporated paneer has greatly increased its therapeutic potential.Objective: The current study was undertaken to explore the effects of carrot incorporated paneer (CIP) on blood glucose, body weight, insulin, and enzymatic antioxidants such as superoxide dismutase, catalase, glutathione (GSH) peroxidase, and reduced GSH in streptozotocin (STZ) and nicotinamide (NAD)-induced diabetes in rats.Materials and Methods: Diabetic rats were orally supplemented with CIP (200 mg/kg body weight/day) for 1 month and the effects were compared with gliclazide (5 mg/kg body weight/day).Results: Supplementation of CIP or gliclazide was resulted in noteworthy diminish in the levels of blood glucose and increase in body weight and insulin levels. STZ-NAD administration caused the diminution in enzymatic antioxidant activities in diabetic rats and supplementation with CIP predominantly enhanced the levels of antioxidant enzymes in diabetic rats when contrasted to diabetic group.Conclusion: Hence, the results suggested that CIP has the potential antioxidant capability and may be believed as an efficient curative constituent for the management of DM.