The effect of six novel complexes of Pt(II) and Pd(II) with pyridine-2-carboxyaldehyde thiosemicarbazone (HPyTsc) on sister chromatid exchange rate and human lymphocyte proliferation kinetic was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing cytogenetic and antineoplastic effects are the complexes [Pd(PyTsc)₂] and [Pt(PyTsc)₂]. Next in order of magnitude in inducing antineoplastic and cytogenetic effects is the compound [Pt(HPyTsc)₂]Cl₂ while the rest, i.e. [Pd(PyTsc)Cl], HPyTsc, [Pd(HPyTsc)₂]Cl₂, and [Pt(PyTsc)Cl], show marginal cytogenetic and antineoplastic effects.

Molecules of the title compound, C14H15N4S÷.C1-. -1.25H20, are linked through intra-and intermolecular hydrogen bonds to form a dimeric structure. The crystal structure of the dimer is stabilized by two intermolecular hydrogen bonds of the N--HN...S type and two intramolecular hydrogen bonds of the N HN...C1 type. The inter-and intramolecular bonds form an eightmembered and a ten-membered ring, respectively.