Presented are the first results of studying the Re-Os isotope system of native gold from the orogenic Malo-Taryny, Khangalas, and Bazovsky deposits located in the central part of the Yana-Kolyma metallogenic belt. Re concentration in the sampled gold varies from 0.168 to 6.997 mg/t while that of Os changes from 0.068 to 1.443 mg/t. The data obtained enabled calculation of the isochrone age which is consistent, within the limits of error, with 40Ar-39Ar and К-Аr dates of sericite from the above deposits. The results obtained indicate that gold deposits under study were formed in the interv of 147.8–137.1 Ma synchronously with Late Jurassic – Early Cretaceous orogenic processes in the Yana-Kolyma metallogenic belt and the eastern margin of the Siberian continent. The initial Os isotope ratios ((187Os/188Os)i= 0.1844–0.2475) in the studied samples and fractions of gold from the Malo-Tarynsky, Khangalas and Bazovsky deposits suggest a significant role of a non-radiogenic component, normally associated with mantle sources.