Introduction: Coronavirus disease-19 infection is caused by the coronavirus and has taken a toll throughout the world. The aim of this study was to find the prevalence of coronavirus disease-19 infection among patients presenting to a tertiary care centre. Methods: A descriptive cross-sectional study was conducted at the fever clinic of a tertiary care centre between January 2021 to September 2021 after receiving ethical approval from the Institutional Review Committee (Reference number: 2011202001). Convenience sampling was done. Data were collected from the records of patients diagnosed with real-time polymerase chain reaction) test in the sample group. Point estimate and 95% Confidence Interval were calculated. Results: Among 230 patients presenting to the fever clinic, 130 (56.52%) (50.11-62.93, 95% Confidence Interval) were diagnosed with coronavirus disease-19. Conclusions: Our study found that the prevalence of coronavirus disease-19 was higher when compared to similar studies conducted in similar settings.