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Artigo mio/metanol 1:1, como um sólido castanho amorfo. O espectro na região do infravermelho (IV) de 1 apresentou bandas de absorção típicas de grupos hidroxila (3361 cm-1) e carboxila de éster (1729 cm-1) além de uma lactona α,β insaturada (1713 e 1659 cm-1). Os dados espectroscópicos de RMN desta substância, evidenciaram a presença de um esqueleto iridoidal caracterizado pelos sinais δ H /δ C em 7,30 (d,

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The crude extract and fractions from the branches of Ixora brevifolia, a tree found in the Brazilian Cerrado, were tested for anti-inflammatory and in vitro antiproliferative effects. The crude extract and n-hexane fraction exhibited significant inhibition of ear oedema in mice, while n-hexane-precipitated and chloroform fractions strongly inhibited the myeloperoxidase activity in ear tissue. The n-hexane and n-hexane-precipitated fractions showed strong growth inhibition for glioma cell line and the hydromethanolic fraction inhibited the growth of leukaemia cell line.

The crude extract and fractions of aerial parts from Psychotria cupularis, collected at Camacan (Brazil), were tested for anti-inflammatory and antiproliferative activity. A phytochemical screening indicated the presence of tannins, anthraquinones, triterpenes, steroids and flavonoids. The crude extract and fractions inhibited the ear oedema in mice between 50.2 to 87.2% and the myeloperoxidase enzyme activity between 51.6 to 97.1%. The butanolic and ethyl acetate fractions was active against glioma, breast, ovary, kidney, colon and leukaemia cell line (IG50 = 4.3 to 16.9 μg/mL).