Over the last few decades, hot melt extrusion (HME) has found extensive adaptability and utility as a viable drug delivery option in the pharmaceutical industry. HME has already been validated as a robust, novel technique mainly used for the correction of solubility and bioavailability of poorly soluble drugs. In line with the scope of the current issue, this review appraises the value of HME as a means of solubility enhancement of BCS class II drugs and presents an influential tool for the manufacturing or production of drugs or chemicals. The drug development process can be shortened with the use of hot melt extrusion technology, and the application of this process to analytical technology can ease the manufacturing process. This review focuses on the tooling, utility, and manufacturing aspects associated with hot melt extrusion technology.