Pancha Harithakadi Churna (PHC) is a traditional polyherbal formulation meant for digestion which consists of household ingredients having digestive property. PHC is mainly used for Constipation and Bloating. Churna’s will play an important role in gastro intestinal problems. Churna’s are having greater bioavailability because of smaller particle size. It consists of fine powder (sieve 100 size) of Ginger rhizomes, Fennel fruits, Myrobalan fruits, Senna leaflets and Pink Rock salt in equal proportions (1:1:1:1:1) are mixed well. PHC is formulated by standard procedures and evaluated by physical and analytical methods. Physicochemical standards and heavy metals are found to be within the limits. PHC is found to be free from microbes. The PHC showed pronounced amylolytic activity and moderate lipolytic and proteolytic activity when compared with standard showing its efficacy for treating indigestion. In future we will carry out other digestive enzymes in vitro studies and also to carry out in vivo digestive studies.

Carcino-sarcoma is a malignant mixed mesodermal neoplasm accounting for less than 1% of all ovarian tumors. It is an aggressive tumor, composed of both malignant epithelial and mesenchymal components. To the best of our knowledge, less than 400 cases of ovarian carcino-sarcomas have been reported in the literature and only 10% of them are bilateral. In this paper, we report a new case of unilateral ovarian carcino-sarcoma in a 20-year-old adolescent girl with the aim to analyze it with its possible differentials, treatment and prognosis due to rarity of its occurrence in young age.

A thirty two year female presented with painless progressive lump in right breast with intermittent high grade fever for 10 days. No other symptoms were present. She was non diabetic, non-hypertensive with insignificant family and menstrual history. On examination there was a tender freely mobile lump of approximately 5×4 cm occupying lower inner quadrant having firm consistency and a centre fluctuant area of 1 cm, the overlying skin was erythematous. A single non tender mobile lymph node was present in the right axilla. Contralateral breast was clinically normal. High resolution sonography revealed cystic lesion from 3-6 O’ clock position and axillary lymphadenopathy. The fine needle aspiration cytology showed microfilariae. Hence, a diagnosis of breast filariasis was made. Fluid aspirated from the cavity came out to be sterile. Patient improved symptomatically on di-ethyl-carbazine citrate (DEC) therapy (6 mg/kg for 2 weeks) and the lump too regressed in size.

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Colonic T cell/histiocyte rich large B cell lymphoma (THRLBCL) is a very unusual occurrence never described before. A 41-year anaemic male presented with loss of weight and appetite for 7 months and fever with Malena for 1 month. Abdominal examination revealed a 4×6 cm retroperitoneal lump in the right iliac fossa. Radiological investigations (USG and CECT whole abdomen) reported an asymmetrical ill-defined growth in ascending colon and caecum with loco-regional lymphadenopathy. Surgical exploration revealed an ascending colon mass with retroperitoneal lymphadenopathy. Right hemi-colectomy with end ileostomy was done and specimen was sent for histopathology which diagnosed it to be a case of THRLBCL of colon. Patient was followed up after 2 weeks and was planned for chemotherapy.