The synthesis of a series of novel substituted benzimidazole derivatives by the condensation of o-phenylenediamine (1) with 4-bromophenoxy acetic acid (2) and subsequent reactions of the benzimidazole with different electrophiles have been reported. The latter compounds were reacted with styrene following Heck Coupling reaction. The synthesized compounds were characterized by IR, 1 H-NMR, Mass and Elemental analysis for their structures. All the synthesized compounds were tested for their potential anti-bacterial and anti-fungal activities. This exhibited some promising results towards testing organism in vitro.