Intussusception is a pediatric condition that is rare in adults. It is usually associated with lead points affecting the intestine. Lipomas are very rare benign tumors which may act as lead points for intestinal intussusception. Indeed, the incidence of intestinal intussusception caused by lipomas is very rare. Our patient is a 38-year-old female, previously healthy and admitted for colicky right lower quadrant abdominal pain of 2-day duration. Computed tomography (CT) scan of the abdomen and pelvis showed a prominent “target sign” in the right lower abdomen which was suggestive of long segment ileocolic intussusception. Urgent laparotomy opted for ileocolic intussusception and right hemicolectomy with end-to-side isoperistaltic ileocolic anastomosis was performed. The pathology report showed that intussusception was induced by a colon lipoma. Thus, ileocolic intussusception caused by lipoma should be considered in the differential when diagnosing adults with right lower quadrant pain.

Histoplasmosis is a rare type of fungal infection which may manifest as a respiratory disease or as a disseminated infection. It is common in immunocompromised patients and, in recent times, seen in association with COVID-19. On histopathological examination, many intracellular and extracellular yeast forms are seen, which can be confirmed by fungal stains. Histoplasmosis involving the nasopharyngeal region is quite rare. Till date, only less than 100 cases of pharyngo-laryngeal histoplasmosis have been reported. Such cases are clinico-radiologically easily and frequently mistaken for malignancy. Here, we report a case that initially had COVID-19-like symptoms and later presented with a nasopharyngeal mass clinico-radiologically mistaken as a nasopharyngeal malignancy. The diagnosis was established on histopathological examination and the patient recovered completely with anti-fungal treatment. A high grade of suspicion and thorough histopathological examination, especially in immunocompromised patients, complimented by fungal special stains is quite rewarding as even a disseminated disease is curable.