It is important to conserve and improve water use efficiency and crop productivity in arid and semi-arid zones. For which, the use of beneficial microorganisms and water retainers can help in the tolerance of plants to drought conditions. Therefore, the objective of this work was to determine the effect of inoculation with MPCV- plant growth promoting microorganisms (Azospirillum brasilense and mycorrhizal fungi) and the application of organic amendment of potassium acrylate on the production of tomato plants (Solanum lycopersicum L.). A greenhouse trial was carried out with a completely randomized experimental design with 4 treatments (T1: Control without application of amendment or MPCV; T2: application of K acrylate amendment; T3: with MPCV inoculation; T4: with joint application of K acrylate amendment and MPCV), with 15 replicates. The highest production and size of tomato fruits was achieved with the inoculation of MPCV (T3) and with the application of K acrylate (T2) individually. The inoculation with Azospirillum brasilense and mycorrhizal fungi, and the application of the organic amendment of potassium acrylate at the time of transplanting tomato (Solanum lycopersicum L.) improves growth and increases its production.