Background. Immune effector cell-associated neurotoxicity syndrome (ICANS) is a relatively common consequence of chimeric antigen receptor T-cell (CAR-T) therapy, with a wide range of possible cognitive presentations. The aim of this study was to characterise a real-word cognitive and psychological status of patients with advanced haematologic and solid organ malignancies planned for CAR-T. We also aimed to examine utility of two cognitive screening approaches. Methods. Patients underwent specialist cognitive assessment, including a self-report questionnaire of psychopathology and subjective cognitive function. A subset of individuals also completed the Montreal Cognitive Assessment (MoCA). Results. Of 60 patients included, 15-16 (25%-27%) presented with evidence of cognitive impairment, with six unique patterns of dysfunction. Impaired patients were more likely to have B-cell acute lymphoblastic leukaemia (BF10=9.30), be younger (BF10=7.76), have bone marrow involvement (BF10=5.18), report history of anxiety (BF10=4.85), or have evidence of psychopathology (BF10=31.30). Analyses did not support the utility of cognitive screening. Of those patients who completed a self-report measure of psychopathology, nine (15.8%) were elevated on at least one symptom domain. Conclusions. The findings demonstrate a broad spectrum of dysfunction and psychopathology in this cohort, emphasising the importance of baseline evaluation for detecting cognitive neurotoxicity symptoms that might arise after CAR-T infusion.

The quality of any purposeful process can be considered as a set of the most essential operational properties that determine its suitability for its intended use. Given the fact that the handling is a characteristic of the communication network, the properties of the management process should be considered from the perspective of the ability of the authorities to implement the tasks in view of the provision of hidden control of troops and weapons. With regard to the study of the quality of communication network management, it is advisable to describe their properties of timeliness (efficiency), effectiveness and resource consumption. At the same time, each of them is complex, has its own structure and is in a certain dependence and relationship with the properties of the system and the properties of the results obtained during its operation. The authors propose the methods for estimating the quality of communication network manageability, describe the properties of efficiency, effectiveness and resource consumption. The quality of decisions is considered in terms of validity, adequacy and protection of information.