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The article studies new approaches to management of regional eco-economic systems in conditions of strong impact on the ecological component of region economy; gives the assessment of influence of relationship between industrial enterprises and territories of their presence; offers tools of realization of corporate social responsibility in the management system of regional eco-economic systems. Environmental problems in the mining region, are especially sharply felt today in the conditions of the current state of economy. This challenge that will require if the wording to use a number of measures of preventive character, in particular use of instruments of realization of the mechanism of social responsibility of business for sustainable social and economic development of the territory. The organizational and economic mechanism will allow to carry out the trial functions providing sustainable social and economic development of territories, acting in the form of the coordinated interaction of the elements providing strengthening of points of body height of functioning of regional ecologic and economic systems.

The article is devoted to the consideration of the regional ecosystem "Education-Science-Industry", the definition of the role of regional universities and scientific institutions in the technological and economic development of regions. The author's vision of strategizing the regional ecosystem "Education-Science-Industry" and the socioeconomic system of the region is presented. The use of digital twins of the regional ecosystem "Education-Science-Industry" and the socioeconomic system of the region in the development of strategies for their development is justified. The role of the laboratory of analysis and forecasting as an element of the institutional infrastructure of regional development in the process of strategizing the regional ecosystem "Education-Science-Industry" and the socioeconomic system of the region is outlined. A unique methodology for assessing the mutual influence of the authors of the regional ecosystem "Education-Science-Industry" and the region has been developed. The classification and ranking of indicators of the methodology for assessing the contribution of the regional ecosystem "Education-Science-Industry" to the development of the region are presented. The results of the work can be useful in the formation of innovative scientific and technological centers, consortia of universities, scientific institutions, and enterprises of the real sector of the regional economy, determining the strategic prospects for their development.

The methodological issues of ensuring the economic sustainability of enterprises, as one of the key goals of modern industrial business, have long been the focus of attention of scientists and researchers, not only because of their importance, but also because of some internal inconsistency that does not allow them to be considered finally resolved. On the one hand, sustainability presupposes stability, some conservatism in the development of the enterprise and this aspect of it requires the application of measures that prevent a sharp change in economic conditions. Attract the attention of researchers and have not yet received their final scientific, methodological and practical solution. It should be believed that the solution of this task, which is important for each industrial enterprise in a market economy, can be found in the case of: (a) the correct definition of business development directions in terms of its diversification and expansion (external dimension); b) determination of such economic conditions that can ensure an equilibrium state of the enterprise’s economy, characterized by a certain set of parameters of the activity of its main subsystems (internal measurement) and c) implementation of the algorithm of periodic controlled withdrawal of the enterprise from the state of stability for transition to a new level of development and stabilization of its socio-economic parameters in the intervals between such fluctuations. Therefore, the purpose of this article is to attempt to resolve this contradiction in terms of developing a set of solutions to create conditions for the progressive dynamics of industrial enterprises that do not impede, but complement, the installation to maintain stability within acceptable limits. For this, the scientific and methodological apparatus of business modeling, modern concepts of organization and management is involved, as well as innovations in the best practice of sustainable development of industrial enterprises are used. The result of the study is a tree of goals for ensuring the economic sustainability of a modern industrial enterprise, revealing the internal dimension of the problem under study and practical recommendations.