The benzimidazole-1,2,3-triazole hybrid 4f selectively interacted with G-quadruplex DNA over duplex DNA, inhibits cell cycle at the G2/M phase, inducing apoptosis, and may be a G-quadruplex DNA groove binder with anticancer activity.

The novel one pot four‐component reaction for the construction of dihydroindolizino[8,7‐b]indoles and their derivatives have been developed from ninhydrine, tryptamine, dimetylene acetylene dicarboxylate and aliphatic alcohol. This reaction produces to go through via Pictet‐Spengler cyclization reaction and construction of C−C and C−N bond readily achieved under transition metal free condition. Meanwhile, advantageous of tandem double cyclization are not only reducing reaction steps but also waste production.

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