Every living organism contains 'Proteins' which are building blocks to perform various functions. Proteomics is the analysis of the whole protein in a genome which tells about the molecular mechanisms of homeostatic cell and regarding external disturbances, such as pathologic or pharmacologic treatment. Proteomics improvized various biomedical fields such as medicine, dentistry, molecular biology, and genetics. This article reviews some of the currently available literature on conducting Proteomic analysis of dental tissues. A literature review is done using electronic databases, such as "PubMed," "Google Scholar," and "Scopus," using keywords "Proteomics," and "Biomarkers." Furthermore, an advanced or refined search was carried out using the keywords "Mass Spectrometry," "Proteins," "Enamel," "Dentin," "Cementum," "Periodontal ligament" and "pulp." Proteomics in dentistry helps in the early diagnosis of healthdisease molecular signatures with the discovery and recognition of numerous biomarkers in biological, pathological or pharmacological processes that are present in the fluids of the oral cavity. This paper explains the role of proteomics in the analysis of oral tissues.

Nanotechnology is the advance science exploiting phenomena and direct manipulation of materials on the nanoscale. It can bring tremendous changes in the fields of medicine and dentistry. In dentistry, there is widespread recognition of microbial as the contributory factor for dental infection. Treatment of infected root canals presents with a significant challenge of bacterial persistence after treatment. Antibacterial Nanoparticles based treatment can improve the antibiofilm efficacy. A day may soon come when Nano dentistry will succeed in maintaining near-perfect oral health through the aid of nanorobotics and nanomaterials.