Highlights d S. aureus causes SPM formation in human M2 macrophages by a-hemolysin d a-hemolysin elicits SPM biosynthesis by activation of 15lipoxygenase-1 in M2 d Inhibition of ADAM10 or 15-lipoxygenase-1 knockdown reverts a-hemolysin actions d a-hemolysin elevates SPM levels in mouse peritoneum devoid of leukocyte influx
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