Pemphigus foliaceus is a chronic autoimmune disease of the skin, clinically
characterized by scaly and crusty cutaneous erosions involving the seborrheic
areas. The patient can eventually become erythrodermic. There are reports of
atypical cases of pemphigus foliaceus with pustules and neutrophils, and
clinical differentiation from generalized pustular psoriasis of von Zumbusch is
difficult. We report the case of a 55-year-old man with a history of psoriasis
vulgaris that has developed pemphigus foliaceus with pustules, triggered by
withdrawal of systemic corticosteroids. This is the first report associating
this atypical form of pemphigus with psoriasis, suggesting that an overlap with
generalized pustular psoriasis can occur.
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