Information sharing (IS) has been considered a vital aspect of supply chain management practices. However, it is inadequate to induce a significant increment in performance, so there is a need for collaboration within the supply chain network arises. This study seeks to determine the position of Information Sharing (IS) practices and Supply Chain Collaboration (SCC) in Firm Performance (FP). The study emphasizes that firms exchange information because of the competitive influence stemming from the business environment. The study administered questionnaires to manufacturing firms in Ghana with 201 respondents, and the structural equation modeling tested the relationship between IS, SCC, and FP. The results indicate that firms with higher levels of IS and SCC witness high-performance rates. Also, supply chain collaboration can have a direct, positive influence on the performance of firms. The study is limited in scope, which lessens the generalization of the results. This study is unique because it simultaneously examines the role of information sharing on both collaboration and firm performance.