Background-The anatomical proximity of the cannabinoid type 1 (CNR1/CB1R) and the dopamine D2 receptors (DRD2), their ability to form CB1R-DRD2 heteromers, their opposing roles in locomotion and their involvement in ethanol's reinforcing and addictive properties, prompted us to study the levels and distribution of CB1R after chronic ethanol intake, in the presence and absence of DRD2.
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