BACKGROUNDBecause of its embryonic origin, the thyroid gland is predisposed to multiple anatomical variations and developmental anomalies. These include the pyramidal lobe, the origin of levator glandular thyroideae, the absence of the isthmus, ectopic thyroid, accessory thyroid tissues, etc. The developmental anomalies and anatomical variations are of clinical significance especially to researchers, anatomists and surgeons. We wanted to study the incidence and clinical implications of pyramidal lobe of the thyroid gland. METHODSA total of 38 male and 12 female properly embalmed cadavers were taken. Neck region was dissected and the thyroid gland was observed for the presence of Pyramidal lobe. RESULTSThe pyramidal lobe of thyroid gland was observed in 17 out of 50 cadavers. CONCLUSIONSHaving knowledge about the anatomical variations of thyroid gland is essential for surgeons and anatomists.HOW TO CITE THIS ARTICLE: Rupanagudi S, Vanisree SK. Study of incidence of pyramidal lobe of the thyroid gland in Rayalaseema region and its clinical implications.