Motivation A single precision value is currently reported for an integrative model. However, precision may vary for different regions of an integrative model owing to varying amounts of input information. Results We develop PrISM (Precision for Integrative Structural Models), to efficiently identify high and low-precision regions for integrative models. Availability PrISM is written in Python and available under the GNU General Public License v3.0 at https://github.com/isblab/prism; benchmark data used in this paper is available at doi:10.5281/zenodo.6241200. Supplementary information Supplementary data are available at Bioinformatics online.