Ten cyanobacterial isolates from the hypersaline environment of Rann of Kutch were characterized for growth related physiological variables. A wide variability was observed in chlorophyll, protein and sugar content among the isolates. Similarly carotenoids, phycoerythrin and allophycocyanin contents also varied among the isolates. Differential activity of antioxidant enzymes such as superoxide dismutase, ascorbate peroxidase, catalase and levels of proline were related to the ability of the strains to survive at higher salinity levels.