Synthesis of series of cross linked polymers of methacrylic acid (PMAs) and acrylic acid ( P U S ) is reported. Polymers of both the types have been investigated f o r physiochemical properties like solubility, density, swelling index and equilibrium swelling. A suitable method was devised for study of bioadhesion. Floating tablets were prepared and coated with some of the synthesized polymers. The tablets were then evaluated for physical properties (including bioadhesion) as well as for drug content and in vitro drug release. The results were compared with those obtained with Carbopol 934P. Some polymers showed better bioadhesion and drug release pattern as compared to Carbopol 934P. * For Correspondance 1. Present address : U.S. Vitamins, Deonar, Bombay -400 088 2. Present address : Ion Exchange (India) Ltd., Ambarnath. a79 Copyright 0 199 1 by Marcel Dekker, Inc. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/27/14 For personal use only. Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/27/14 For personal use only.pH of Suspension : The pH of a 0 . 5 % suspension of polymer in deionised water and in 0.5% carbopol 934 P gel was read. The aqueous supensions gave pH in the range of 4.15 to 4.55. Addition of the polymer to carbopol further reduced pH of suspension to between 3.7 and 3 . 8 .Effect of DH on Eauilibrium Swellins of Polvmers : A 0.1% suspension of the polymer was prepared in deionised water, Drug Dev Ind Pharm Downloaded from informahealthcare.com by University of Otago on 12/27/14For personal use only.

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