Because of active advancement in the field of biomedicine, people have in-depth knowledge of biological nature of malignant tumors and are able to recognized the overexpression of different molecules such as vascular endothelial growth factor receptor, cyclin-dependent kinase, and programmed cell death receptor. Presently, various targeted therapeutic drugs are used in different clinical trials in those patients suffering from oral squamous cell carcinoma. In this review, we converse about the various targeted therapeutic drugs and their advancement in the treatment of oral squamous cell carcinoma. This review scrutinizes the existing documentation in the literature related to the targeted therapies for oral squamous cell carcinoma. English language articles were searched in various databases such as PubMed, Scopus, Science Direct, and Google Scholar. The keywords used for searching are “oral squamous cell carcinoma,” “targeted therapy,” and “therapeutic drugs.”

The accurate examination of oral cavity may acknowledge findings that demonstrate the presence of underlying systemic, which helps in earlier diagnosis as well as treatment. The oral tissues are accountable to damage as a disease consequence that primarily affects other body systems. Various systemic diseases show oral manifestation. Some of these oral conditions include oral ulcers, caries, dry mouth, gingival bleeding, and gingival hypertrophy. This review article is prepared to make general physicians as well as dentist aware about systemic disorders or conditions that show dental or oral manifestation. AbstractKeywords ► oral manifestations ► systemic diseases ► disorders

Context: Residual ridge resorption(RRR) affect the patient’s satisfaction with complete denture by decreasing the sulcus / vestibular depth, Aims: The aim of this study is to find the correlation between difference in sulcus / vestibular depth by intraoral examination and on master cast/ old denture with patient’s satisfaction from complete denture. Settings and Design: The study included old denture wearer and complete denture prosthesis made by different operators in the college. Methods and Material: The vestibular sulcus depths at 7 different sites in edentulous maxilla and 12 different sites in edentulous mandible  and respective flange height in maxillary and mandibular denture were measured. Prevalidated questionnaire was used to measure the satisfaction of patients with denture. Statistical analysis used:  Pearson correlation was done to find the correlation between satisfaction score and difference in sulcus / vestibular depth. Results: The difference in sulcus depth in maxilla with maxillary cast and mandible with mandibular master cast/ denture showed medium to large negative correlation with p value 0.01. The increase in difference will lead to decrease in satisfaction score of patients.

Oral carcinogenesis is known as multifactorial process which engaged plentiful genetic events that transform normal activity of tumor suppressor genes and oncogenes. It is observed that aggregation of genetic alterations is the ground for  advancement of a normal cell to cancer cells, which is known as a multi-step carcinogenesis. Because of this event, growth factor production increases as well as increase in total of receptors on cell surface and increased intracellular signal messengers. The present review scrutinize the existing documentation in the literature related to the oral squamous cell carcinoma. English language articles were searched in various databases such as Pubmed, Scopus, Science direct and Google scholar. The keyword used for searching are “oral squamous cell carcinoma”, “Genetics and Oral squamous cell carcinoma”,“Molecular mechanism in oral squamous cell carcinoma”. The present review spotlights on understanding the molecular mechanism and the genetic factors which is responsible for alteration in the cell which leads to oral squamous cell carcinoma.

Biomaterials are the materials that are used for the restoration and reorganization of various tissues as well as organs. Some of the common materials presently used are organic, metallic, and composites. To increase the biocompatibility of these materials, some types of coatings are regularly applied. Hydroxyapatite is one of the materials which is mostly used for coating these materials. Hydroxyapatite acquires the same structural and chemical characteristics as human bone. In the present review, we discussed the various aspects of hydroxyapatite coatings that consist of rationale, coating process, various techniques, and coating failures.