Interpersonal distress is a common feature in gambling disorder and adding a concerned significant other (CSO) to the recovery process could be an effective tool for improving treatment outcome. However, little empirical evidence is available regarding the effectiveness of including a CSO to interventions. We aimed to compare treatment outcomes (i.e. compliance with therapy guidelines, dropout from treatment, and relapse during treatment) in a CBT program involving a CSO to CBT treatment as usual (TAU) without a CSO. The sample comprised male gambling disorder patients (N = 675). The manualized CBT intervention consisted of 16 weekly outpatient group sessions and a 3-month follow-up period. Patient CSOs attended a predetermined number of sessions with the patient and were provided with resources to acquire a better understanding of the disorder, to manage risk situations, and to aid patients in adhering to treatment guidelines. Patients with a CSO had significant higher treatment attendance and reduced dropout compared to patients receiving TAU. Moreover, patients whose spouse was involved in the treatment program were less likely to relapse and adhered to the treatment guidelines more than those with a non-spousal CSO. Our results suggest that incorporating interpersonal support to gambling disorder interventions could potentially improve treatment outcomes.

Lactoferrin and lysozyme are 2 glycoproteins with great antimicrobial activity, being part of the nonspecific defensive system of human milk, though their use in commercial products is difficult because human milk is a limited source. Therefore, many investigations have been carried out to produce those proteins in biological systems, such as bacteria, yeasts, or plants. Mammals seem to be more suitable as expression systems for human proteins, however, especially for those that are glycosylated. In the present study, we developed a bicistronic commercial vector containing a goat β-casein promoter and an internal ribosome entry site fragment between the human lactoferrin and human lysozyme genes to allow the introduction of both genes into bovine adult fibroblasts in a single transfection. Embryos were obtained by somatic cell nuclear transfer, and, after 6 transferences to recipients, 3 pregnancies and 1 viable bitransgenic calf were obtained. The presence of the vector was confirmed by fluorescent in situ hybridization of skin cells. At 13 mo of life and after artificial induction of lactation, both recombinant proteins were found in the colostrum and milk of the bitransgenic calf. Human lactoferrin concentration in the colostrum was 0.0098 mg/mL and that in milk was 0.011 mg/mL; human lysozyme concentration in the colostrum was 0.0022 mg/mL and that in milk was 0.0024 mg/mL. The molar concentration of both human proteins revealed no differences in protein production of the internal ribosome entry site upstream and downstream protein. The enzymatic activity of lysozyme in the transgenic milk was comparable to that of human milk, being 6 and 10 times higher than that of bovine lysozyme present in milk. This work represents an important step to obtain multiple proteins or enhance single protein production by using animal pharming and fewer regulatory and antibiotic-resistant foreign sequences, allowing the design of humanized milk with added biological value for newborn nutrition and development. Transgenic animals can offer a unique opportunity to the dairy industry, providing starting materials suitable to develop specific products with high added value.

El impacto de la variable tecnológica dentro de las organizaciones ha sido tratado con diversos enfoques por muchos autores. Se ha hecho referencia a la forma en la que la tecnología influye en la competitividad, la productividad y el desempeño de las organizaciones. Sin duda, las organizaciones poseen tecnología pero ¿Cómo evaluarla? Por su importancia, el problema de evaluación tecnológica se ha estudiado por Naciones Unidas (UNIDO, 1996), haciendo énfasis en el lugar que ocupa esta actividad dentro del proceso de planeación para la transferencia de tecnología. Casi siempre el tratamiento del concepto de evaluación tecnológica se ha hecho de manera muy general sin considerar que las características de la tecnología varían y se modifican a lo largo de su ciclo de vida. Este

Since late 1990's in the first world was proposed a new mission for the public universities beyond the teaching and research and development (R&D); their conversion as agents for economic development through the knowledge transferred to other society organizations. More than twenty years have passed and now we can see that in practice achieving this has been very difficult for public universities of developing countries. In the case of the Mexican Centre presented, it is shown that public University have historically established strong links with other public governmental organizations and that the technology and the knowledge products delivered through the years, have had important social impact but no economical. Therefore, we propose that an important factor is that university R&D entities must develop stronger links with both, private companies and public organizations. Case shows that this phenomenon not only depends on the linking system performance, but also of the lack of the innovation culture among domestic entrepreneurs. The conclusion is that today's role of the public university in Mexico is the generation and knowledge transference for the social welfare and that it is

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