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Background and Objective: Chrysin and its derivatives proved to possess potential anti-tumour activity. Materials and Methods: A new series of chrysin analogs containing 1,2,3-triazoles with different substituent groups (5a-5l) was designed, synthesized, and evaluated as potential anticancer agents. The synthesized compounds were characterized using FT-IR, 1H NMR 13C NMR spectroscopy and mass spectrometry. Resulsts: The anticancer activities of the synthesized compounds were studied in four cancer cell lines viz.PC3, PC3-PSMA, MCF-7 and UM-UC-3 using doxorubicin as standard. Among all the tested compounds 5c was found as most active with IC50 value of 10.8 ± 0.04 µM in PC3 cells and 20.53 ± 0.21 µMin MCF-7 cells respectively. Flow cytometry analyses indicated that synthesized compounds 5a,5c and 5h arrested MCF-7 cells at the G2/M phase in a dose-dependent manner. Conclusion: Chyrsin derivatives could be novel anticancer agents.

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