Interleukin-6 (IL-6) exerts pro-as well as anti-inflammatory activities in response to infection, injury, or other stimuli that affect the homeostasis of the organism. IL-6-induced expression of acute-phase protein genes in the liver is tightly regulated through both IL-6-induced feedback inhibitors and the activity of proinflammatory cytokines such as tumor necrosis factor ␣ and interleukin-1. In previous studies mechanisms for how
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