Introduction Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown etiology characterized by increased intracranial pressure, resulting in headaches, pulsatile tinnitus, and papilledema. A major risk factor for IIH is obesity, and weight management can help improve symptoms of IIH. Venous sinus stenting is a surgical intervention aimed at resolving IIH. This study aims to evaluate the effect of venous sinus stenting on post-operative body mass index (BMI) changes in IIH patients. Secondary objective is to determine post-operative BMI changes by papilledema resolution. Methods Consecutive patients undergoing venous sinus stenting for IIH who have been diagnosed with papilledema were retrospectively reviewed from two comprehensive North American cerebrovascular centers. Patient demographics, surgical course, and post-operative outcomes and weight were calculated. A systematic review and meta analysis of post-operative weight in stented IIH patients with papilledema was conducted to determine BMI changes. Results Thirty patients with a diagnosis of idiopathic intracranial hypertension (IIH) and papilledema who underwent venous sinus stenting were identified across two institutions. All subjects were female, with a mean age of 32.8 ± 2.8. At 3-month follow up, the mean BMI decreased by 1.57%, increasing to 1.80% at 6 months; at the last follow up, there was a mean decrease of 2.19% in BMI. Average follow up was 6.02 ± 1.50 months. Systematic review revealed one study that met all inclusion criteria for the meta-analysis, containing 13 patients, yielding a total of 35 patients. The mean age was 31.23 ± 1.88 years and BMI decreased by 0.15% at 3-month follow up, and further decreased by 1.80% at 6 months. Last follow up displayed a mean decrease of 2.19% in BMI. Average follow up was 6.02 ± 1.50 months. Statistical analysis showed no significant difference in percent change regardless of whether or not papilledema resolved. Conclusions In conclusion, this study demonstrated that venous sinus stenting may result in modest decreases in BMI in IIH patients. The evidence suggests that with the intervention of venous sinus stenting, patients experienced a decrease in their BMI regardless of papilledema resolution. Further research such as larger prospective trials are needed to further understand the effect of transverse sinus stenting on weight loss.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.