andibular distraction osteogenesis was made popular in the modern era by Joseph McCarthy in the 1990s. 1 The process consists of three components 1,2 : (1) performing a mandibular osteotomy to create a gap in the bone, (2) placement of hardware across the osteotomy that is attached to both the mesial and distal pieces of bone, and (3) the gradual activation

Introduction: Acne vulgaris is the most common skin condition worldwide, and it is associated with substantial psychological comorbidity. Topical therapies-including retinoids, antibiotics, and benzoyl peroxide-are the cornerstones of treatment for patients with acne. The main barriers to care in the treatment of acne are poor adherence to therapy and lack of tolerability.Areas covered: Herein, the authors review the safety and efficacy of adapalene/benzoyl peroxide combination gel (0.1%/2.5% and 0.3%/2.5%), as well as its specific mechanisms of action that target acne vulgaris. The authors also offer an expert opinion on the use of adapalene/benzoyl peroxide gel compared with other topical therapies.Information Classification: General Expert opinion: Adapalene/benzoyl peroxide gel is safe and highly effective in the treatment of acne vulgaris. Its efficacy, tolerability, and ease-of-use are superior to other topical acne therapies, and its use does not contribute to antibiotic resistance. However, the cost of adapalene/benzoyl peroxide gel and lack of available generics may prohibit its use.

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