In the course of a screening for cytotoxic compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC 50 -values of 0.5ϳ3 mg/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).

No abstract

The new heterocyclic spiro terpenoid niveulone (1) was isolated from the cultural fluid of the ascomycete Dasyscyphus niveus, and its chemical structure and relative configuration were determined by spectroscopic techniques.

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Terpenes U 0200The Dasyscyphins A-C and Niveulone, New Biologically Active Compounds from the Ascomycete Dasyscyphus niveus. -Whereas dasyscyphin A (I) does not exhibit significant biological activity, dasyscyphins B (II) and C (III) show cytotoxic activity against human HepG2, Hela S3, U937, Colo-320 and Jurkat cell lines with IC50 of 0.5 ≈ 3 ug/ml. The activity of niveulone (IV) is less pronounced. -(MIERAU, V.; ROJAS DE LA PARRA, V.; STERNER, O.; ANKE*, T.; J.