The aim of this study is to compare the efficiency of Platelet-rich plasma (PRP) in the treatment of acute lesions and chronical disease of bones, joints and nerves from forearm, wrist and hand. Material and Methods: articles published in English between 2008 and 2018 from medical literature were selected. Results: when it comes to acute lesions three articles were found; one about the using of PRP in distal radius fractures and the two about the infiltration of PRP in the complete neurotmesis of radial nerve or in digital nerve incomplete section. In chronic conditions only one article about trapeziometacarpian (TMC) osteoarthritis (OA) was found, and three articles about a median nerve compression in carpal tunnel syndrome (CTS). Conclusions: 1.The medical literature contains few publications regarding the efficiency of PRP in treatment of traumatic lesions and chronic disease of forearm, wrist and hand. 2. In chronic conditions the favorable outcomes after the PRP injection are obtained only in the first stage of the disease, in advanced stages the surgical treatment is mandatory.