Contributors: Shay Brikman conceived the work and wrote the draft. Veronika Denysova, Husam Menzal and Guy Dori analyzed and interpreted the data and revised the manuscript critically for important intellectual content. All of the authors gave final approval of the version to be published and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.