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This article deals with metabolic-immune processes at rest and under stress conditions, which, in turn, results in the development of immune-dependent and immune-associated disorders. The article analyzes study results and conclusions of various literature sources and experimental data in healthy individuals and patients suffering from non-specific inflammatory lung diseases; purulent-inflammatory diseases and their combinations, primary and secondary progressive multiple sclerosis in the acute stage and remission. Research studies investigated the impact of the type, stage, combination of diseases on the parameters of the immunologic and metabolic statuses, as well as their correlations. The authors also analyzed metabolic effects of immunomodulators. Based on the analysis of the literature and own clinical and experimental data, the authors identified the ability of metabolic factors to regulate immunological processes. A correlative analysis of examination results of the patients with various diseases helped detect the unity of the immune-metabolic mechanisms of pathology. The data on the therapeutic effect of various modulators through differentiated biochemical chains and vice versa -the metabolic effect through immunological mechanisms -were analyzed in the study. Thus, one can testify that there is the phenomenon of a mediated effect of some immunocorrectors on the reactivity through metabolic chains. The fact that a number of modulators and metabolics can simultaneously affect the biochemical and immunological parameters of patients proved the above phenomenon. There was revealed a significant correlation interaction of the immune-metabolic parameters with various types of purulent-inflammatory diseases, which proves the formation of a single mechanism of pathology. Keywordsimmunomodulators, immunotropic effect, immuno-metabolic parameters, metabolics.Note: parameters of the standard formulas of the immune system disorders and metabolic disorders included in the key risk factors are given in bold; GP -glutathione reductase, GR -glutathione reductase, CIC -circulating immune complexes, VE -vitamin E, NK -natural killers, MDA -malonic dialdehyde, PPMS -primary progressive forms, SPMS -secondary progressive forms.

The article discusses the problem of immune response complexity, found in functional unity of regulatory systems, cooperation of immunocompetent cells, connection and regulation of specific and non-specific defence mechanisms, association of immune, routine laboratory and clinical parameters under normal and pathological conditions. The article reviews the influence of disease combinations, their comprehensive treatment on immunopathology, and the corrector effects. To reproduce natural mechanisms of homeostasis regulation, complex, blocking immunotherapy of diseases is suggested.

2 Institute of surgery named after A. V. Vishnevsky, Moscow, Russian Federation Аннотация При анализе литературы и собственных данных охарактеризованы классификации, виды вакцин и сывороточных препаратов, показания, противопоказания, способы введения, длительность сохранения эффектов, осложнения, методы профилактики и коррекции. Ключевые словаВакцины, сыворотки, иммунотерапия, иммунопрофилактика. SummaryWhen analyzing the literature and own data is characterized by classification, types of vaccines and serum drugs, indications, contraindications, methods of administration, the duration of the preservation effects, complications, methods of prevention and correction.

This article describes subsystems of the immunityskin, mucous membranes, ear, throat and nose organs, the respiratory, digestive and urinary tracts. It covers opportunities of the targeted correction of their functional violations that can influence targeted immunotherapy options.