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Acne vulgaris is a chronic inflammatory disorder of the skin. Low level of adherence to acne patients to treatment can lead to poor clinical efficacy, increased healthcare costs, and unnecessary treatments that can lead to adverse drug reactions. The aim of this study is to compare the level of adherence to acne patients between Greece and Bulgaria. A multicenter observational study utilized self-completed questionnaires to assess medication adherence among patients visiting 45 pharmacies throughout Bulgaria and Greece between May and December 2018. A total of 225 patients were included in the study. Subjects included acne patients undergoing treatment who had a medical consultation prior to the study. All patients had acne therapy prescriptions. The likelihood of adherence was assessed using the Elaboration díun outil díevaluation de líobservance (ECOB) Adherence Questionnaire. Adherence Questionnaire. The ECOB scale was translated into Bulgarian and standardized by forwarding translation, backward translation, and a pretest. The data collected were proceeded through SPSS ver. 22.0. According to the ECOB scores, good adherence to treatment was documented in 42.0% of the Bulgarian patients on topical treatment and 39 on oral medication. For the Greek patients, good adherence to topical medication was judged to be good for 53% and 40% in oral treatment. Greek and Bulgarian patients show a similar level of adherence to acne treatment ñ a high rate of non-adherence. Perhaps patients could be monitored about their adherence and this can be performed in the dermatology clinic or the pharmacy.

The aim of this study is: 1) To evaluate vitamin D serum levels of fullterm newborns and its association with the maternal levels; 2) To evaluate the diet and the intake of multivitamin supplements of women; 3) To analyze seasonal dependence in serum levels of mother-baby pairs. The prospective study was carried out between July 2018 and February 2020 at the University Hospital of Obstetrics and Gynecology “Maichin dom”, Sofia. The study included 45 full-term newborns and their mothers. Data collected included maternal health, nutrition, vitamin intake, and anthropometric data of the newborns. The laboratory tests performed: maternal serum 25(OH)D levels taken in the third trimester of pregnancy and umbilical cord levels of 25(OH)D. The results show that the mean birth weight was 3234.22 ± 370.29 g and the mean gestational age was 38.13±0.89 weeks. A 25(OH)D sufficiency was found in 58% of mothers and 67% of newborns. A strong positive correlation between maternal and neonatal 25(OH)D concentrations (p = 0.007) was found. A relationship between maternal diet, vitamin supplementation and serum vitamin D levels was observed. The level of 25(OH)D in the umbilical cord in winter is lower than in summer (p = 0.002). Due to the essential role of vitamin D for the normal development of the fetus and the infant, a testing for serum levels of vitamin D during pregnancy is recommended.

UMBALSM "Pirogov" РЕЗЮМЕ Ендометриозата е хронично естроген-зависимо заболяване, което се характеризира с развитие на ендометриална тъкан извън маточната кухина. В световен мащаб засяга около 10% от жените. Заболяването може да причини дисменорея, хронична тазова болка, диспареуния и инфертилитет. Медикаментозното лечение играе ключова роля в контрола на заболяването. В повечето случаи е наложително лекарствената терапия да бъде комбинирана с хирургична, за да бъде постигнато пълно излекуване. Подходът при избор на подходящо медикаментозно лечение трябва да бъде индивидуализиран, като бъде съобразен с тежестта на ендометриозата, ефикасността на лекарството, страничните му ефекти, желанието на пациентката, възрастта ѝ и репродуктивните ѝ планове. Голяма част от използваните днес лекарства за лечение на ендометриоза целят потискане на овариалната функция. Най-често прилаганите и показващи най-добри резултати са комбинираните орални контрацептиви, аналозите на гонадотропин-освобождаващия хормон и прогестините. Освен тези утвърдени терапии, съвременното лечение включва и нови хормонално и нехормонално-базирани терапевтични подходи, които модулират различни патогенетични механизми. В този обзор ще бъдат разгледани настоящите терапевтични опции-както класическите, така и по-новите, все още неодобрени медикаменти за лечение на ендометриоза.

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