Presented patient, as well as most other patients with MM progressing to CN Sinfiltration was in the stage III. In addition to the detailed clinical examination, and all investigations required for MM diagnosis and staging of the disease, we introduced the additional CSF examination and calculation of kappa lambda ratio, that helped us make an early diagnosis and prognosis of MM with LMM. Although LMM had a low prevalence, it could be more frequent than expected especially in patients with high risk. CSF examination with positive plasma cells and abnormal morphology remains the hallmark for diag nosing CNS infiltration.

Kratak sadr`aj: Serumski test slobodnih lakih lanaca meri nivoe imunoglobulinskih slobodnih k i l lakih lanaca. Tri su glavne indikacije za primenu serumskog testa slobodnih lakih lanaca u proceni i le~enju multiplog mijeloma i srod nih plazma }elijskih poreme}aja. U kontekstu skrininga, test slobodnih lakih lanaca u kombinaciji sa elektroforezom proteina seruma i imunofiksacijom doprinosi visokoj osetlji vo sti, ~ime se izbegava upotreba 24-~asovnih urinarnih testo va za otkrivanje amiloidoznih lakih lanaca. Re fe rentna merenja slo bodnih lakih lanaca imaju veliku progno sti~ku vrednost za gotovo sve plazma }elijske poreme }aje. Test slo bodnih lakih lanaca omogu}ava kvanti ta tivno pra}enje bo lesnika sa oligosekre tornim plazma }eli j skim po re me}ajima, uklju~uju}i primar nu, sistemsku AL ami lo idozu, oligose kre torni mijelom, i oko 2/3 bolesnika sa nesekre tornim multi plim mijelomom. Kod bolesnika sa pri mar nom, sistemskom AL amiloidozom, se rijska merenja slo bodnih lakih lanaca prevazilaze testove elektroforeze pro teina i imu nofiksacije. Kod bolesnika sa oligosekretornim mijelo mom, iako nefor mal no validirana, se rijska merenja slobodnih lakih lanaca umanjuju potrebu zã estim bio psi jama ko{tane sr`i. Na suprot tome, ne postoji podr{ka za primenu testa slobodnih lakih lanaca umesto 24-asovne urinarne elektroforeze za pra}enje ili serijska me renja plazma }elijskih poreme}aja, koja se mogu izmeriti serum skom ili urinarnom elektro fo rezom.Klju~ne re~i: serumski slobodni laki lanci, preporuke, test slobodnih lakih lanaca, plazma }elijski poreme}aji

Tropinins are ideal markers which enable early detection of patients with acute coronary syndrome, whereas inflammation markers are helpful in diagnosing and assessing the severity of inflammation.

Investigations have proved that the use of beta-blockers reduces the development of cerebrovascular accidents, heart insufficiency and hypertension. Despite strong arguments and numerous recommendations, beta-blockers have not been accepted to a sufficient extent as an integral part of treatment of acute coronary syndrome and related diseases, to the detriment of many lost lives and in spite of favourable pharmaco-economic aspect.

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