In this work, the bivariate calibration algorithm is proposed as an alternative for the resolution of binary mixtures using derivative spectrophotometry. This algorithm involves the use of four calibration curves: two for each compound at two different wavelengths, selected by Kaiser's method. Four binary mixtures were studied (tartrazine-allura red; sunset yellow-erythrosine B; tartrazine-riboflavine and acetylsalycilic acid-caffeine) as representative examples where their 2563 ORDER REPRINTS resolution with the conventional zero-crossing technique is not suitable and, in each case, rather good analytical results were obtained using the bivariate method.

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