Background: Acute leukemia is the most common malignant disease in children. Patient typically die for complications, there occur as a consequence of treatment and the disease itself. Objectives: To describe the rate and the clinical, paraclinical features of common complications in acute leukemia patients before and during induction therapy. Subjects & methods: A survey was conducted with 34 acute leukemia patients at The Pediatric Center in Hue Central Hospital from 4/2017 to 7/2018. Results: Infection were the most common complication as a percentage of 91.2%, the propotion of severe anemia and severe hemorrhage were at 85.3% and 35.3%. Conclusions: The percentage of infection, severe anemia and severe hemorrhage decreased in period of the last 2 weeks of induction therapy, in which the proportion of severe anemia declined significantly in statistics. Neutrophil counts, platelet counts and hemoglobin levels were significantly increased when patients entered to the last 2 weeks of induction therapy. Key words: complication, acute leukemia, induction therapy